FIRE (400,000 BCE): The controlled use of fire was an invention in the early Stone Age, with some of the earliest evidence dating back to hundreds of thousands of years age. It's not exactly certain when fire was first being used by humans, but most research puts it somewhere between 200,000 and 600,000 years ago.
WHEEL (3400 BCE): The next significant step in the history of innovation came with the creation of the wheel, sometime between 3300 and 3500 BCE We know this thanks to the discovery in southern Poland of the earliest known depiction of a wheeled vehicle on a claay pot.
MONEY (3000 BCE): The next critically important innovation that contributed to the development of a strong human civilization was money. Around 3000 BCE, the Sumerians were one of the first societies (if not the first) to begin using money to help the ease of commerce and exchanging of goods, replacing the barter system.